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Université de Bordeaux

Pierre Justeau

Photographie

Postdoctoral Fellowship in Palaeogenomics

UMR PACEA 5199
University of Bordeaux
Bât B2
Allée Geoffroy Saint-Hilaire CS 50023
33615 PESSAC Cedex

GPR Human Past - WP 1 Action 3

pierre.justeau%40u-bordeaux.fr

Research Interests

Over the last few years I have had the opportunity to develop various research interests:

  • Studying the neolithization and the Bronze Age transition in Western Europe through ancient DNA
  • Studying the advent of the Anglo-Saxon and the Merovingian dynasty through ancient DNA
  • Developing a pipeline written in Python to use the graph theoretical approach to depict sex-biased dispersal and coevolution in ancient populations: mitochondrial DNA vs. Y-chromosome variation. I also use the graph to analyze IBD.
  • Using prediction tools to determine the possible impact of an amino acid substitution on the structure and function of a human protein across the genome
  • Analyzing differential gene expression from RNAseq data.

Curriculum Vitae

Current Position

November 2022

Postdoctoral Fellowship in Palaeogenomics - PACEA (UMR 5199 CNRS / Univ Bordeaux) – GPR Human Past. Name of supervisors: Marie-France Deguilloux, Mélanie Pruvost

Education

2018-2022

PhD in bioinformatics – palaeogenomics “Sex-specific processes in European prehistory and beyond: Y-chromosome, mitochondrial DNA and genome-wide variation - University of Huddersfield

2017      

Master’s degree in Bioinformatics and Genomics -  University of Rennes 1

2014

Master’s degree in Biological Anthropology - University of Bordeaux

Professional Work Experience

Field Laboratory

2021-2022    

Engineer in bioinformatic, Laboratoire ADES, University of Aix-Marseille

2017-2022   

PhD student, University of Huddersfield

Archaeological Field Experience

  • Les Pradelles, Marillac-le-France (August 2012). Director : Bruno Maureille (PACEA)
  • Caune de l’Arago, Tautavel (June 2012). Directors: Henry de Lumley (MNHM) and Tony Chevalier (UPVD)
  • Malvieu, Saint-Pons-de-Thomières (August 2011). Director : Alexis Gorgue (Ausonius)
  • Tumulus de Celles, Neussargues. Director : Lionel Izac Imbert (TRACES)

Technical Skills

  • Programming languages:
    • Proficient in programming in Python and Bash, good understanding in Java, SQL, and R
  •  Bioinformatics:
    • Strong skills in the use of:
    • Bioinformatics packages to manipulate High-throughput sequencing data such as fastQC, cutadapt/leeHom, Bowtie2, BWA, samtools, GATK, ANGSD, PLINK/EIGENSOFT, VCFtools and BCFtools.
    • Bioinformatics packages to manipulate RNAseq data such as STAR, stringtie and the R Bioconductor DESeq2 for analyzing differential gene expression.
    • To manipulate datasets using file formats such as PLINK/EIGENSOFT .fastq, .vcf, .fasta, .gdf, .nwk.
    • To use phylogenetics, networks and graphs software such as Blast, MEGA, mtPhyl, pathPhynder, Haplogrep, Network 4.6.1.2, Gephi, Cytoscape
    • To use softwares to infer population histories from genetic data such as the packages ADMIXTOOL, qpAdm,
    • To use tools to predict the possible impact of an amino acid substitution on the structure and function of a human protein, such as Polyphen 2, fathmm, panther and IMOTHEP.
  • Molecular techniques:
    •  Strong skills in DNA extraction for human samples, DNA purification, library preparation for illumina HiSeq platform.

 

Publications

Gretzinger, J., Sayer, D., Justeau, P., Altena, ED., Pala, M., Dulias, K., Edwards, C.J. ...  (48 coauthors) ... Powlesland, D., Kenyon, R., Ladle, L. ... (16 coauthors) ... Richards, M.B., Reich, D., Krause, J., Schiffels, S. (2022) The Anglo-Saxon migration and the formation of the Early English gene pool. Nature. https://doi.org/10.1038/s41586-022-05247-2

Dulias, K*., Foody, M.G.B*., Justeau, P*., Silva, M., Martiniano, R., Oteo-García, G., Fichera, A., Rodrigues, S., Gandini, F., Meynert, A., et al. (2022). Ancient DNA at the edge of the world: Continental immigration and the persistence of Neolithic male lineages in Bronze Age Orkney. Proceedings of the National Academy of Sciences 119, e2108001119. https://doi.org/10.1073/pnas.2108001119.4

Moore H., Wilson G., Ni Challanain M., McCormick M., Marshall P.D., Dulias K., Foody M.G.B., Justeau P., Pala M., Richards M.B. & Edwards C.J. (2022) Bronze Age Orkney: Some new perspectives from recent work at Links of Noltland. Antiquity, first view: https://doi.org/10.15184/aqy.2021.185

Silva, M., Oteo-García, G., Martiniano, R., Guimarães, J., von Tersch, M., Madour, A., Shoieb, T, Fichera, A., Justeau, P., Foody, M.G.B., McGrath, K., Barrachina, A., Palomar, V., Dulias, K., Yau, B., Gandini, F., Clarke, D.J., Rosa, A., Brehm, A, Flaquer, A., Rito, T., Olivieri, A., Achilli, A., Torroni, A., Gómez-Carballa, A., Salas, A., Bryk., J., Ditchfield, P.W., Alexander, M., Pala, M., Soares, P.A., Edwards, C.J., and Richards, M.B. (2021) Biomolecular insights into North African-related ancestry, mobility and diet in eleventh-century Al-Andalus. Sci Reports 11:181221. 10.1038/s41598-021-95996-3

Silva, M., Justeau, P., Rodrigues, S., Oteo-Garcia, G., Dulias, K., Foody, G., Fichera, A., Yau, B., Rito, T., Wilson, J.F., Gandini, F., Edwards, C.J. Pala, M., Soares, P.A., and Richards, M.B. (2019) Untangling Neolithic and Bronze Age mitochondrial lineages in South Asia. Annals of Human Biology, 46:140-144. 10.1080/03014460.2019.1623319

 Dulias, K., Birch, S., Wilson, J.F., Justeau, P., Gandini, F., Flaquer, A., Soares, P., Pala, M., Richards, M.B., and Edwards, C.J. (2019) Maternal relationships within an Iron Age burial at the High Pasture Cave, Isle of Skye, Scotland. Journal of Archaeological Sciences 110:104978. https://doi.org/10.1016/j.jas.2019.104978

*equal contribution